BVD 10

Cat. No. 2177

BVD 10 Ile-Asn-Pro-Ile-Tyr-Arg-Leu-Arg-Tyr-OMe

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Biological Activity

Highly selective NPY Y1 receptor antagonist. Ki values are 25.7, 1420, 2403 and 7100 nM at Y1, Y2, Y4 and Y5 receptors respectively. Devoid of agonist activity at Y4 receptors.

Licensing Information

Sold under license

Technical Data

M.Wt:
1221.46
Formula:
C58H92N16O13
Sequence:
INPIYRLRY

(Modifications: Tyr-9 = Tyr-OMe)

Solubility:
Soluble to 1 mg/ml in 20% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
262418-00-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Jois et al (2006) Modeling of neuropeptide receptors Y1, Y4, Y5, and docking studies with neuropeptide antagonist. J.Biomol.Struct.Dyn. 23 497. PMID: 16494499.

Jois and Balasubramaniam (2003) Conformation of neuropeptide Y receptor antagonists: structural implications in receptor selectivity. Peptides 24 1035. PMID: 14499282.

Balasubramaniam et al (2001) Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90). J.Med.Chem. 44 1479. PMID: 11334558.

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Keywords: BVD 10, supplier, selective, Y1, antagonists, devoid, Y4, agonists, activity, Neuropeptide, Y, Receptors, NPY, BVD10, neuropeptides, Tocris Bioscience, NPY Receptor Antagonist products

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