Cat. No. 2176
Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]in
Biological ActivityNon-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 < 10 μM).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711. PMID: 14747616.
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Citations are publications that use Tocris products. Selected citations for BVT 948 include:
Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533. PMID: 24152909.
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