Cat. No. 2176
Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]in
Biological ActivityNon-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 < 10 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711. PMID: 14747616.
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Citations are publications that use Tocris products. Selected citations for BVT 948 include:
Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533. PMID: 24152909.
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