AMT hydrochloride

Cat. No. 0871

AMT hydrochloride C5H10N2S.HCl [21463-31-0]

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Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride

Biological Activity

Potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).

Technical Data

Soluble to 10 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Liao et al (2006) Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes. FASEB J. 20 E1196. PMID: 16877524.

Yu et al (2005) Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes. J.Physiol. 566 327. PMID: 15845578.

Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831. PMID: 7536889.

If you know of a relevant reference for AMT hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for AMT hydrochloride include:

Lee et al (2016) Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents. PLoS One 24 67. PMID: 26759704.

Messlinger et al (2000) Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat. Br J Pharmacol 129 1397. PMID: 10742295.

Zanardo et al (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A 94 14111. PMID: 9391161.

Do you know of a great paper that uses AMT hydrochloride from Tocris? If so please let us know.

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Keywords: AMT hydrochloride, supplier, Potent, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, Tocris Bioscience, iNOS Inhibitor products

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