Cat. No. 0254
Chemical Name: (S)-α-Amino-3-hydroxy-5-methyl-4-iso
Biological ActivityActive enantiomer of AMPA (EC50 = 3.5 μM). Also available as part of the AMPA Receptor Tocriset™ (Cat. No. 1822). NPEC-caged-(S)-AMPA (Cat. No. 3840), inactive enantiomer (R)-AMPA (Cat. No. 0253) and racemate (RS)-AMPA (Cat. No. 0169) are also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513. PMID: 9651156.
Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668. PMID: 2859375.
Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901. PMID: 6133955.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-AMPA include:
Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. PLoS One 6 7066. PMID: 25967870.
Pooler et al (2013) Physiological release of endogenous tau is stimulated by neuronal activity. J Neurosci 14 389. PMID: 23412472.
Oh et al (2012) Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells. EMBO Rep 7 e47846. PMID: 23110111.
Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Proc Natl Acad Sci U S A 31 3077. PMID: 21414928.
Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962. PMID: 20694145.
Limon et al (2007) Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus. Neuroreport 104 15526. PMID: 17881566.
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Keywords: (S)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, Tocris Bioscience, AMPA Receptor Agonist products