Cat. No. 0254
Chemical Name: (S)-α-Amino-3-hydroxy-5-methyl-4-iso
Biological ActivityActive enantiomer of AMPA (EC50 = 3.5 μM). Also available as part of the AMPA Receptor Tocriset™ (Cat. No. 1822). NPEC-caged-(S)-AMPA (Cat. No. 3840), inactive enantiomer (R)-AMPA (Cat. No. 0253) and racemate (RS)-AMPA (Cat. No. 0169) are also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Falch et al (1998) Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships. J.Med.Chem. 41 2513. PMID: 9651156.
Lauridsen et al (1985) Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors. J.Med.Chem. 28 668. PMID: 2859375.
Hansen et al (1983) Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. J.Med.Chem. 26 901. PMID: 6133955.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-AMPA include:
Jackson et al (2010) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS One 5 e11962. PMID: 20694145.
Do you know of a great paper that uses (S)-AMPA from Tocris? If so please let us know.
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Keywords: (S)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, Tocris Bioscience, AMPA Receptor Agonist products
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