(RS)-AMPA

Cat. No. 0169

(RS)-AMPA C7H10N2O4 [74341-63-2]

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Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Biological Activity

Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. Active enantiomer (S)-AMPA (Cat. No. 0254), inactive enantiomer (R)-AMPA (Cat. No. 0253) and hydrobromide salt (RS)-AMPA hydrobromide (Cat. No. 1074) also available.

Technical Data

M.Wt:
186.17
Formula:
C7H10N2O4
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
74341-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173. PMID: 6125564.

Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64. PMID: 6101908.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (RS)-AMPA include:

Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606. PMID: 20826795.

Schenk et al (2003) Regulated delivery of AMPA receptor subunits to the presynaptic membrane. EMBO J 22 558. PMID: 12554656.

Do you know of a great paper that uses (RS)-AMPA from Tocris? If so please let us know.

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Keywords: (RS)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, Tocris Bioscience, AMPA Receptor Agonist products

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