(RS)-AMPA

Cat. No. 0169

(RS)-AMPA C7H10N2O4 [74341-63-2]

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Chemical Name: (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

Biological Activity

Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. Active enantiomer (S)-AMPA (Cat. No. 0254), inactive enantiomer (R)-AMPA (Cat. No. 0253) and hydrobromide salt (RS)-AMPA hydrobromide (Cat. No. 1074) also available.

Technical Data

M.Wt:
186.17
Formula:
C7H10N2O4
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
74341-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Honore et al (1982) The binding of 3H-AMPA, a structural analogue of glutamic acid, to rat brain membranes. J.Neurochem. 38 173. PMID: 6125564.

Krogsgaard-Larsen et al (1980) New class of glutamate agonist structurally related to ibotenic acid. Nature 284 64. PMID: 6101908.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (RS)-AMPA include:

Angelantonio et al (2015) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci 9 409. PMID: 26528137.

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. PLoS One 10 e0131430. PMID: 26102354.

Netzahualcoyotzi and Tapia (2015) Degeneration of spinal motor neurons by chronic AMPA-induced excitotoxicity in vivo and protection by energy substrates. Acta Neuropathol Commun 3 27. PMID: 25968178.

Nygaard et al (2015) Melanoma brain colonization involves the emergence of a brain-adaptive phenotype. Oncoscience 1 82. PMID: 25593989.

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports 3 282. PMID: 25254342.

Fakira et al (2012) Purkinje cell dysfunction and delayed death in plasma membrane calcium ATPase 2-heterozygous mice. Mol Cell Neurosci 51 22. PMID: 22789621.

Mahajan et al (2011) Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing. Neuroscience 189 305. PMID: 21620933.

Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606. PMID: 20826795.

Biou et al (2008) Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc Natl Acad Sci U S A 105 1038. PMID: 18195348.

Schenk et al (2003) Regulated delivery of AMPA receptor subunits to the presynaptic membrane. EMBO J 22 558. PMID: 12554656.

Do you know of a great paper that uses (RS)-AMPA from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: (RS)-AMPA, supplier, Selective, AMPA, agonists, Glutamate, Receptors, iGluR, Ionotropic, Tocris Bioscience, AMPA Receptor Agonist products

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