Cat. No. 1111
Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,
Biological ActivityAgonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.
Licensing InformationSold with the permission of the CNRS
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Chapman et al (2001) Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107. PMID: 11476756.
De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17. PMID: 10771029.
Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119. PMID: 9301676.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ACPT-I include:
Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99. PMID: 24402869.
Do you know of a great paper that uses ACPT-I from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ACPT-I, supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Selective mGlu2 receptor positive allosteric modulator
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.