ACPT-I

Cat. No. 1111

ACPT-I C8H11NO6 [194918-76-8]

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Chemical Name: (1S,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid

Biological Activity

Agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice.

Licensing Information

Sold with the permission of the CNRS

Technical Data

M.Wt:
217.18
Formula:
C8H11NO6
Solubility:
Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
Storage:
Desiccate at -20°C
CAS No:
194918-76-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Chapman et al (2001) Anticonvulsant activity of a mGlu receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107. PMID: 11476756.

De Colle et al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17. PMID: 10771029.

Acher et al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119. PMID: 9301676.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ACPT-I include:

Domin et al (2014) Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Proc Natl Acad Sci U S A 26 99. PMID: 24402869.

Do you know of a great paper that uses ACPT-I from Tocris? If so please let us know.

View Related Products by Target

Keywords: ACPT-I, supplier, Group, III, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products

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