Pyrrolidinedithiocarbamate ammonium

Cat. No. 0727

Pyrrolidinedithiocarbamate ammonium C5H12N2S2 [5108-96-3]

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Alternative Name: PDTC

Biological Activity

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bessho et al (1994) Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem.Pharmacol. 48 1883. PMID: 7986199.

Eberhardt et al (1994) Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells. Biochem.Biophys.Res.Commun. 200 163. PMID: 7513157.

Schini-Kerth (1994) Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta. Eur.J.Pharmacol. 265 83. PMID: 7533726.

If you know of a relevant reference for Pyrrolidinedithiocarbamate ammonium please let us know.

Citations are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:

Nadeem (2017) IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression. Cytokine 97 14. PMID: 28570931.

Ishizuka et al (2016) PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages Scientific Reports 6 32092. PMID: 27554194.

Lin et al (2015) Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis. J Neurosci 5 12463. PMID: 26198099.

Wang et al (2015) Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling. Sci Rep 15 821. PMID: 26514586.

Muxel et al (2013) NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. BMC Cancer 7 e52010. PMID: 23284853.

Birmingham et al (2009) Novel mechanism for obesity-induced colon cancer progression. Carcinogenesis 30 690. PMID: 19221001.

Do you know of a great paper that uses Pyrrolidinedithiocarbamate ammonium from Tocris? If so please let us all ▼show less ▲

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