Cat. No. 1189
Biological ActivityHighly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).
(Modifications: Leu-1 = N-terminal Ac)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ihara et al (1995) [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur.J.Pharmacol. 274 1. PMID: 7768260.
Reynolds et al (1995) Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 209 506. PMID: 7733918.
Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887. PMID: 7921617.
Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547. PMID: 8473300.
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Citations are publications that use Tocris products. Selected citations for BQ-3020 include:
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Cell Death Dis 32 14489. PMID: 23077035.
Do you know of a great paper that uses BQ-3020 from Tocris? If so please let us know.
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Keywords: BQ-3020, supplier, Selective, ETB, agonists, Receptors, Endothelin, Tocris Bioscience, ETB Receptor Agonist products
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High affinity dual ETA and ETB receptor antagonist;orally bioavailable
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