BQ-3020

Cat. No. 1189

BQ-3020 Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

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Biological Activity

Highly potent and selective ETB endothelin receptor agonist (Ki values are 0.18 and 970 nM at human ETB and ETA receptors respectively).

Technical Data

M.Wt:
2006.35
Formula:
C96H140N20O25S
Sequence:
LMDKEAVYFAHLDIIW

(Modifications: Leu-1 = N-terminal Ac)

Solubility:
Soluble to 0.50 mg/ml in sodium bicarbonate (0.03M)
Storage:
Desiccate at -20°C
CAS No:
143113-45-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Ihara et al (1995) [3H]-BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur.J.Pharmacol. 274 1. PMID: 7768260.

Reynolds et al (1995) Pharmacological differences between rat and human endothelin B receptors. Biochem.Biophys.Res.Commun. 209 506. PMID: 7733918.

Ekelund et al (1994) Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle. Br.J.Pharmacol. 112 887. PMID: 7921617.

Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J.Biol.Chem. 268 8547. PMID: 8473300.

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Keywords: BQ-3020, supplier, Selective, ETB, agonists, Receptors, Endothelin, Tocris Bioscience, ETB Receptor Agonist products

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