[D-Ala2]-Deltorphin II

Cat. No. 1180

[D-Ala2]-Deltorphin II Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2

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Biological Activity

Selective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.

Technical Data

M.Wt:
782.89
Formula:
C38H54N8O10
Sequence:
YAFEVVG

(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
122752-16-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Sanchez-Blazquez (1998) Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J.Pharmacol.Exp.Ther. 285 820. PMID: 9580632.

Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J.Pharmacol.Exp.Ther. 281 817. PMID: 9152390.

Mattia et al (1991) Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J.Pharmacol.Exp.Ther. 258 583. PMID: 1650835.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:

Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93. PMID: 24059654.

Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861. PMID: 22016519.

Do you know of a great paper that uses [D-Ala2]-Deltorphin II from Tocris? If so please let us know.

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Keywords: [D-Ala2]-Deltorphin II, supplier, Selective, δ-opioid, delta-opioid, agonist, peptide, DOP, Receptors, OP1, [D-Ala2]-DeltorphinII, Tocris Bioscience, δ Opioid Receptor Agonist products

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