Cat. No. 1180
Biological ActivitySelective peptide agonist for the δ opioid receptor. Antinociceptive in vivo.
(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sanchez-Blazquez (1998) Delta opioid receptor subtypes activate inositol-signalling pathways in the production of antinociception. J.Pharmacol.Exp.Ther. 285 820. PMID: 9580632.
Thomas et al (1997) Structure-activity relationships of a series of [D-Ala2] deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J.Pharmacol.Exp.Ther. 281 817. PMID: 9152390.
Mattia et al (1991) Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes. J.Pharmacol.Exp.Ther. 258 583. PMID: 1650835.
If you know of a relevant reference for [D-Ala2]-Deltorphin II please let us know.
Citations are publications that use Tocris products. Selected citations for [D-Ala2]-Deltorphin II include:
Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Arthritis Res Ther 172 642. PMID: 24827408.
Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93. PMID: 24059654.
Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861. PMID: 22016519.
Do you know of a great paper that uses [D-Ala2]-Deltorphin II from Tocris? If so please let us know.
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