4-Aminopyridine

Cat. No. 0940

4-Aminopyridine C5H6N2 [504-24-5]

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Alternative Name: 4-AP

Biological Activity

Non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data

M.Wt:
94.12
Formula:
C5H6N2
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
504-24-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Smith et al (2009) In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 36 1104. PMID: 19413590.

Tseng (1999) Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 290 569. PMID: 10411564.

Tseng et al (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 279 865. PMID: 8930194.

Bouchard and Fedida (1995) Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 275 864. PMID: 7473178.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4-Aminopyridine include:

Dinamarca et al (2016) Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. Elife 5. PMID: 26977767.

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Front Cell Neurosci 35 5664. PMID: 25855180.

Curcio et al (2015) Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. J Neurosci 6 e1645. PMID: 25675305.

Robinson et al (2015) Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. J Neurosci 9 404. PMID: 26500501.

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Front Neural Circuits 4. PMID: 25723967.

Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. J Neurosci 3 282. PMID: 25254342.

Grace et al (2014) Identification of a pharmacological target for genioglossus reactivation throughout sleep. Elife 37 41. PMID: 24470694.

Leal et al (2014) Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons. PLoS One 9 e108175. PMID: 25286195.

Chanda et al (2013) Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. J Biol Chem 110 16622. PMID: 24046374.

Gaamouch et al (2012) Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci 32 10767. PMID: 22855824.

Hagiwara et al (2012) Optophysiological analysis of associational circuits in the olfactory cortex. Cell Death Dis 6 18. PMID: 22529781.

Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Sleep 32 3992. PMID: 22442066.

Saliba et al (2012) Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current. J Neurophysiol 31 2937. PMID: 22531784.

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757. PMID: 22302815.

Fontán-Lozano et al (2011) The A-current modulates learning via NMDA receptors containing the NR2B subunit. PLoS One 6 e24915. PMID: 21966384.

Restituito et al (2011) Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci 31 12083. PMID: 21865451.

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352. PMID: 20405049.

Sun (2009) Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV. EMBO J 102 2955. PMID: 19741102.

Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258. PMID: 18711223.

Han et al (2007) Dopaminergic modulation of spinal neuronal excitability. J Neurophysiol 27 13192. PMID: 18045913.

Lenz and Avruch (2005) Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. Stem Cell Reports 280 38121. PMID: 16183639.

Do you know of a great paper that uses 4-Aminopyridine from Tocris? If so please let us know.show all ▼show less ▲

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