4-Aminopyridine

Cat. No. 0940

4-Aminopyridine C5H6N2 [504-24-5]

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Alternative Name: 4-AP

Biological Activity

Non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Technical Data

M.Wt:
94.12
Formula:
C5H6N2
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
504-24-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Smith et al (2009) In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin.Exp.Pharmacol.Physiol. 36 1104. PMID: 19413590.

Tseng (1999) Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments. J.Pharmacol.Exp.Ther. 290 569. PMID: 10411564.

Tseng et al (1996) Reverse use dependence of Kv4.2 blockade by 4-aminopyridine. J.Pharmacol.Exp.Ther. 279 865. PMID: 8930194.

Bouchard and Fedida (1995) Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J.Pharmacol.Exp.Ther. 275 864. PMID: 7473178.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 4-Aminopyridine include:

Leal et al (2014) Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons. PLoS One 9 e108175. PMID: 25286195.

Gaamouch et al (2012) Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity. J Neurosci 32 10767. PMID: 22855824.

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757. PMID: 22302815.

Fontán-Lozano et al (2011) The A-current modulates learning via NMDA receptors containing the NR2B subunit. PLoS One 6 e24915. PMID: 21966384.

Restituito et al (2011) Synaptic autoregulation by metalloproteases and γ-secretase. J Neurosci 31 12083. PMID: 21865451.

Gómez-Gonzalo et al (2010) An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. PLoS Biol 8 e1000352. PMID: 20405049.

Léveillé et al (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22 4258. PMID: 18711223.

Do you know of a great paper that uses 4-Aminopyridine from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: 4-Aminopyridine, supplier, K+, channel, blocker, Potassium, Channels, voltage-gated, voltage-dependent, Kv, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, Tocris Bioscience, Voltage-gated Potassium (KV) Channel Blocker products

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