Cat. No. 1465
Biological ActivityEndogenous agonist peptide for the ghrelin receptor (GHS-R1a). Produced mainly by the stomach, it stimulates release of growth hormone from the pituitary gland in vitro and in vivo, and regulates feeding, growth and energy production.
Licensing InformationThis peptide is distributed under license from Dr. Kangawa
(Modifications: Ser-3 = Ser(n-octanoyl))
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Inu (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat.Rev.Neurosci. 2 551. PMID: 11483998.
Tolle et al (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat. Neuroendocrinology 73 54. PMID: 11174017.
Kojima et al (1999) Ghrelin is growth-hormone-releasing acylated peptide from stomach. Nature 402 656. PMID: 10604470.
If you know of a relevant reference for Ghrelin (rat) please let us know.
Citations are publications that use Tocris products. Selected citations for Ghrelin (rat) include:
Lee et al (2016) The Anti-apoptotic Effect of Ghrelin on Restraint Stress-Induced Thymus Atrophy in Mice. Immune Network 16 242. PMID: 27574503.
Aliparasti et al (2015) Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats. Front Behav Neurosci 5 195. PMID: 26236657.
Bavil et al (2015) Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats. PLoS One 5 315. PMID: 26504752.
Bell et al (2015) Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Adv Pharm Bull 6 7066. PMID: 25967870.
Parent et al (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Int J Obes (Lond) 9 284. PMID: 26578914.
Plasse et al (2015) Modulation of cue-induced firing of ventral tegmental area dopamine neurons by leptin and ghrelin. Mol Metab 39 1742. PMID: 26183405.
Taati et al (2015) Effects of Ghrelin on germ cell apoptosis and proinflammatory cytokines production in Ischemia-reperfusion of the rat testis. Nat Commun 13 85. PMID: 25999997.
Tan et al (2014) Ablation of AgRP neurons impairs adaption to restricted feeding. Br J Pharmacol 3 694. PMID: 25352998.
Torres-Fuentes et al (2014) Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract. Adv Pharm Bull 9 e103118. PMID: 25068823.
Romero-Picó et al (2013) Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin. J Lab Autom 38 1296. PMID: 23348063.
Schellekens et al (2013) Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem 288 181. PMID: 23161547.
Watterson et al (2012) Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. Neurosignals 21 28. PMID: 22456226.
Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Iran J Reprod Med 145 234. PMID: 14551228.
Tucci et al (2004) The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Neuropsychopharmacology 143 520. PMID: 15381634.
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Keywords: Ghrelin (rat), supplier, Endogenous, ghrelin, receptor, agonist, GHS-R1a, Receptors, Growth, Hormone, Secretagog, Receptor, 1a, Ghrelin, acylated, Tocris Bioscience, Ghrelin Receptor Agonist products
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