Cat. No. 0721
Chemical Name: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(
Biological ActivityH2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Xie et al (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorg.Med.Chem.Lett. 16 3886. PMID: 16730977.
Hirschfield et al (1992) Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. J.Med.Chem. 35 2231. PMID: 1613748.
Ruat et al (1990) Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc.Natl.Acad.Sci.USA 87 1658. PMID: 2308927.
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Keywords: Aminopotentidine, supplier, H2, antagonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H2 Receptor Antagonist products