Aminopotentidine

Cat. No. 0721

Aminopotentidine C26H35N7O2 [140873-26-3]

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Chemical Name: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide

Biological Activity

H2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.

Technical Data

M.Wt:
477.6
Formula:
C26H35N7O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
140873-26-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Xie et al (2006) Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine. Bioorg.Med.Chem.Lett. 16 3886. PMID: 16730977.

Hirschfield et al (1992) Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor. J.Med.Chem. 35 2231. PMID: 1613748.

Ruat et al (1990) Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes. Proc.Natl.Acad.Sci.USA 87 1658. PMID: 2308927.

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Keywords: Aminopotentidine, supplier, H2, antagonists, Receptors, Histamine, histaminergic, Tocris Bioscience, Histamine H2 Receptor Antagonist products

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