Cat. No. 1171
Alternative Name: DAGO
Chemical Name: [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin
Biological ActivityHighly selective peptide agonist for the μ opioid receptor.
(Modifications: Ala-2 = D-Ala, Phe-4 = N-methyl-Phe, Gly-5 = Gly-ol)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fang et al (1989) Opioid receptors (DAGO-enkephalin, dynorphin A(1-13), BAM 22P) microinjected into the rat brainstem: comparison of their antinociceptive effect and their effect on neuronal firing in the rostral ventromedial medulla. Brain Res. 501 116. PMID: 2572306.
Hirning et al (1985) Studies in vitro with ICI 174,864, [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383. PMID: 2987739.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for DAMGO include:
Bai et al (2015) Sex differences in peripheral mu-opioid receptor mediated analgesia in rat orofacial persistent pain model. J Neurosci 10 e0122924. PMID: 25807259.
Beaudry et al (2015) Regulation of μ and δ opioid receptor functions: involvement of cyclin-dependent kinase 5. Invest Ophthalmol Vis Sci 172 2573. PMID: 25598508.
Liu et al (2015) Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats. J Biomed Sci 22 79. PMID: 26385355.
Ong et al (2015) Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking. J Neurosci 172 615. PMID: 24819092.
Taylor et al (2015) Microglia disrupt mesolimbic reward circuitry in chronic pain. Br J Pharmacol 35 8442. PMID: 26041913.
Wang et al (2015) Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors. PLoS One 19 2587. PMID: 26153065.
Brewer et al (2014) Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Front Neural Circuits 8 62. PMID: 24966815.
Kharmate et al (2013) Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells. Cancer Cell Int 13 93. PMID: 24059654.
Rajasekaran et al (2013) Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol 269 100. PMID: 23537664.
Vicente-Sánchez et al (2013) HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain 6 42. PMID: 24093505.
Zhou et al (2013) Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem 288 36703. PMID: 24187130.
Reyes et al (2012) Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Exp Neurol 233 205. PMID: 22001156.
Beaudry et al (2011) Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli. Neurochem Res 31 13068. PMID: 21917790.
Krook-Magnuson et al (2011) Ivy and neurogliaform interneurons are a major target of μ-opioid receptor modulation. J Neurosci 31 14861. PMID: 22016519.
Lee et al (2011) Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors. Br J Pharmacol 36 2008. PMID: 21671107.
Hull et al (2010) The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy. J Pharmacol Exp Ther 332 1127. PMID: 20008489.
Lorier et al (2010) Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy. PLoS One 5 e8766. PMID: 20098731.
Garzón et al (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine. Mol Pain 5 11. PMID: 19284549.
Kokkola et al (2005) S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol 6 21. PMID: 15850493.
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Keywords: DAMGO, supplier, Selective, μ-opioid, mu-opioid, agonist, MOP, Receptors, OP3, Tocris Bioscience, μ Opioid Receptor Agonist products
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