Cat. No. 2172
Alternative Name: AQZ-1
Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-d
Biological ActivitySelective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).
Licensing InformationSold with the permission of AstraZeneca UK Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Scott et al (2003) Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis. J.Pharmacol.Exp.Ther. 304 433. PMID: 12490620.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for AZ 10417808 include:
Cruz et al (2013) High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis 7 e2073. PMID: 23437413.
Do you know of a great paper that uses AZ 10417808 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: AZ 10417808, supplier, Selective, non-peptide, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, AZ10417808, AstraZeneca, Tocris Bioscience, Caspase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective high affinity MMP2 inhibitor(R)-MG 132
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitor
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for ISSCR 2017.