Z-DEVD-FMK

Cat. No. 2166

Z-DEVD-FMK Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone

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Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone

Biological Activity

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.

Technical Data

M.Wt:
668.67
Formula:
C30H41FN4O12
Sequence:
DEVD

(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

Solubility:
Soluble to 13.37 mg/ml in DMSO
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215. PMID: 10693954.

Kugawa et al (2000) Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930. PMID: 10963298.

Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057. PMID: 9774422.

If you know of a relevant reference for Z-DEVD-FMK please let us know.

Citations are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

Wu et al (2016) Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication Nature Communications 7 13150. PMID: 27748395.

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. BMB Rep 6 9173. PMID: 25823819.

Im-aram et al (2013) The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells. PLoS One 8 e75455. PMID: 24086535.

Woo et al (2012) Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem 287 3963. PMID: 22117079.

Do you know of a great paper that uses Z-DEVD-FMK from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Z-DEVD-FMK, supplier, Cell-permeable, irreversible, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, Tocris Bioscience, Caspase Inhibitor products

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