Cat. No. 2165
Chemical Name: Benzyloxycarbonyl-Val-Asp(OMe)-Val-
Biological ActivityIrreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
(Modifications: Val-1 = Z-Val, Aps-2 = Asp(OMe), Asp-5 = (OMe)-fluoromethylketone)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Robertson et al (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J.Biol.Chem. 277 29803. PMID: 12065594.
Meguro et al (2001) Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells. Stroke 32 561. PMID: 11157197.
Gamen et al (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes Dym loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp.Cell Res. 258 223. PMID: 10912804.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Z-VDVAD-FMK from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Z-VDVAD-FMK, supplier, Irreversible, caspase-2, inhibitors, inhibits, Caspases, Proteinases, Proteases, Tocris Bioscience, Caspase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailable
March 18 - 22, 2017
Little Rock, ARK, USA