Cat. No. 2162
Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthr
Biological ActivityInhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA 101 7554.
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Citations are publications that use Tocris products. Selected citations for INCA-6 include:
Bretz et al (2015) NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Exp Eye Res 5 14963. PMID: 26527057.
Faralli et al (2015) NFATc1 activity regulates the expression of myocilin induced by dexamethasone. Nat Chem Biol 130 42614. PMID: 25450062.
Savage et al (2015) RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS One 10 e0116941. PMID: 25617622.
Do you know of a great paper that uses INCA-6 from Tocris? If so please let us know.
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Keywords: INCA-6, supplier, inhibitors, inhibits, calcineurin, Protein, Ser/Thr, Phosphatases, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products
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