Bax channel blocker

Cat. No. 2160

Bax channel blocker C19H21Br2N3O.2HCl [329349-20-4]

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Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

Biological Activity

Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.

Technical Data

Soluble to 5 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bombrun et al (2003) 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem. 46 21.

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Keywords: Bax channel blocker, supplier, inhibitors, inhibits, Bax-mediated, mitochondrial, cytochrome, c, release, Bcl-2, Family, Tocris Bioscience, Bcl-2 Family Inhibitor products

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