Flecainide acetate

Cat. No. 1470

Flecainide acetate C17H20F6N2O3.C2H4O2 [54143-56-5]

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Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetate

Biological Activity

Open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rouet and Ducouret (1994) Use-and concentration-dependent effects of flecainide in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177. PMID: 7526048.

Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251. PMID: 6395762.

Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821. PMID: 874956.

If you know of a relevant reference for Flecainide acetate please let us know.

Citations are publications that use Tocris products. Selected citations for Flecainide acetate include:

Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691. PMID: 24798465.

Do you know of a great paper that uses Flecainide acetate from Tocris? If so please let us know.

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Keywords: Flecainide acetate, supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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