Cat. No. 1470
Chemical Name: N-(2-Piperidylmethyl)-2,5-bis-(2,2,
Biological ActivityOpen Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rouet and Ducouret (1994) Use-and concentration-dependent effects of flecainide in guinea pig right ventricular muscle. J.Cardiovasc.Pharmacol. 24 177. PMID: 7526048.
Singh et al (1984) The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. Ann.N.Y.Acad.Sci. 17 251. PMID: 6395762.
Banitt et al (1977) Antiarrhythmics. 2. Synthesis and antiarrhythmic activity of N-(piperidylalkyl)trifluoroethoxybenzamides. J.Med.Chem. 20 821. PMID: 874956.
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Citations are publications that use Tocris products. Selected citations for Flecainide acetate include:
Yu et al (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Neurosci 9 e96691. PMID: 24798465.
Do you know of a great paper that uses Flecainide acetate from Tocris? If so please let us know.
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Keywords: Flecainide acetate, supplier, Cardiac, Na+, channel, blockers, Antiarrhythmic, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products
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