Cat. No. 1193

Melittin Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

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Biological Activity

Inhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.

Technical Data


(Modifications: Gln-26 = C-terminal amide)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811. PMID: 9663445.

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753. PMID: 1847132.

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358. PMID: 2122563.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Melittin include:

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Do you know of a great paper that uses Melittin from Tocris? If so please let us know.

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Keywords: Melittin, supplier, Inhibitors, inhibits, Gs, stimulates, stimulators, Gi, activity, protein, kinases, C, cAMP-dependent, G, Proteins, Heterotrimeric, PKC, Tocris Bioscience, G Protein (Heterotrimeric) products

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