Melittin

Cat. No. 1193

Melittin Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

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Biological Activity

Inhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.

Technical Data

M.Wt:
2847
Formula:
C131H229N39O31
Sequence:
GIGAVLKVLTTGLPALISWIKRKRQQ

(Modifications: Gln-26 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
20449-79-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Fukushima et al (1998) Melittin, a metabostatic peptide inhibiting Gs activity. Peptides 5 811. PMID: 9663445.

Raynor et al (1991) Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin. J.Biol.Chem. 266 2753. PMID: 1847132.

Mousli et al (1990) G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. TiPS 11 358. PMID: 2122563.

If you know of a relevant reference for Melittin please let us know.

Citations are publications that use Tocris products. Selected citations for Melittin include:

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Do you know of a great paper that uses Melittin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Melittin, supplier, Inhibitors, inhibits, Gs, stimulates, stimulators, Gi, activity, protein, kinases, C, cAMP-dependent, G, Proteins, Heterotrimeric, PKC, Tocris Bioscience, G Protein (Heterotrimeric) products

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