UK 370106

Cat. No. 2900

UK 370106 C35H44N2O5 [230961-21-4]

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Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid

Biological Activity

Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.

Technical Data

M.Wt:
572.73
Formula:
C35H44N2O5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
230961-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110.

Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750.

Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514. PMID: 12877590.

If you know of a relevant reference for UK 370106 please let us know.

Citations are publications that use Tocris products. Selected citations for UK 370106 include:

Agren et al (2015) Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. J Biol Chem 94 44531. PMID: 25457675.

Do you know of a great paper that uses UK 370106 from Tocris? If so please let us know.

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Keywords: UK 370106, supplier, selective, MMP-3, MMP-12, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, UK370106, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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