Cat. No. 2900
Chemical Name: (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-
Biological ActivityHighly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Matthews et al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356 110.
Whitlock et al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 17 6750.
Fray et al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514. PMID: 12877590.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses UK 370106 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UK 370106, supplier, selective, MMP-3, MMP-12, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, Proteinases, Proteases, UK370106, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Adam 17 (TACE) and MMP inhibitor; orally bioavailableRitonavir
HIV-1 and HIV-2 protease inhibitorAcetyl Pepstatin
High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinasesONO 6818
High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally activeTM 5275 sodium salt
Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailableSacubitril calcium
Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
September 20 - 22, 2016