nTZDpa

Cat. No. 2150

nTZDpa C22H15Cl2NO2S [118414-59-8]

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Chemical Name: 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid

Biological Activity

Potent, selective non-thiazolidinedione PPARγ partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.

Technical Data

M.Wt:
428.33
Formula:
C22H15Cl2NO2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
118414-59-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Berger et al (2003) Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol.Endocrinol. 17 662. PMID: 12554792.

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Keywords: nTZDpa, supplier, Potent, selective, PPARγ, PPARgamma, partial, agonists, Peroxisome, Proliferator-activating, Receptors, Tocris Bioscience, PPARγ Agonist products

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