Cat. No. 1471
Chemical Name: (R)-1-(1-Phenylethyl)-1H-imidazole-
Biological ActivityGeneral anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABAA receptors. Short acting and potent hypnotic, with low toxicity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Moody et al (1998) Distinct structural requirements for the direct and indirect actions of the anaesthetic etomidate at GABAA receptors. Toxicol.Lett. 100-101 209. PMID: 10049144.
Belelli et al (1997) The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 94 11031. PMID: 9380754.
Giese et al (1983) Etomidate: a new intravenous anesthetic induction agent. Pharmacother. 3 251. PMID: 6359080.
If you know of a relevant reference for Etomidate please let us know.
Citations are publications that use Tocris products. Selected citations for Etomidate include:
Rodgers et al (2015) Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. Proc Natl Acad Sci U S A 35 9707. PMID: 26134653.
Do you know of a great paper that uses Etomidate from Tocris? If so please let us know.
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Keywords: Etomidate, supplier, GABA, mimetic, modulatory, agent, GABAA, Receptors, Tocris Bioscience, GABAA Receptor Modulator products
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August 20 - 24, 2017
Paris , France