Cat. No. 1469
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono
Biological ActivityPotent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432. PMID: 1671593.
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791. PMID: 1972895.
Pozza et al (1990) Electrophysiological characterization of a novel potent and orally active NMDA receptor antagonist: CGP 37849 and its ethylester CGP 39551. Eur.J.Pharmacol. 182 91. PMID: 1976098.
If you know of a relevant reference for CGP 37849 please let us know.
Citations are publications that use Tocris products. Selected citations for CGP 37849 include:
Sowa et al (2015) Prenatal stress enhances excitatory synaptic transmission and impairs long-term potentiation in the frontal cortex of adult offspring rats. PLoS One 10 e0119407. PMID: 25749097.
Do you know of a great paper that uses CGP 37849 from Tocris? If so please let us know.
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Keywords: CGP 37849, supplier, Potent, selective, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP37849, Tocris Bioscience, NMDA Receptor Antagonist products