Cat. No. 1468
Biological ActivityAgonist peptide derived from the N-terminus of protease-activated receptor-2 (PAR2). Activates PAR2 (EC50 ~ 5 μM) and facilitates gastrointestinal transit in mice in vivo. Control peptide LRGILS-NH2 (Cat. No. 3394) also available.
(Modifications: Leu-6 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kawabata et al (2001) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br.J.Pharmacol. 133 1213. PMID: 11498505.
Al-Ani et al (1995) Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can.J.Physiol.Pharmacol. 73 1203. PMID: 8564891.
Nystedt et al (1994) Molecular cloning of a potential proteinase activated receptor. Proc.Natl.Acad.Sci.U.S.A. 91 9208. PMID: 7937743.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SLIGRL-NH2 include:
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912. PMID: 24876278.
Antoniak et al (2013) Protease activated receptor-2 contributes to heart failure. EMBO J 8 e81733. PMID: 24312345.
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. PLoS One 30 582. PMID: 21139565.
Vellani et al (2010) Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol Pain 6 61. PMID: 20875131.
Vidwan et al (2010) Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30 2587. PMID: 20930172.
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Keywords: SLIGRL-NH2, supplier, PAR2-activating, peptide, Receptors, Protease-Activated, proteinase-activated, Tocris Bioscience, Protease-Activated Receptor Agonist products
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