Cat. No. 2148
Alternative Name: McN 5652-Z
Chemical Name: (6R,10bS)-rel-1,2,3,5,6,10b-Hexahyd
Biological ActivityPotent, high affinity serotonin re-uptake inhibitor; selective in vivo. Displays moderate selectivity over noradrenalin and dopamine re-uptake in vitro (Ki values are 0.68, 2.9 and 36.8 nM for inhibition of serotonin, noradrenalin and dopamine uptake respectively in rat brain synaptosomes). Potently potentiates 5-HT-induced effects in vivo following oral administration. Biological activity resides predominantly in the (+)-enantiomer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Smith et al (1991) Effects of pyrroloisoquinoline enantiomers ((+)- and (-)-McN-5652-Z) on behavioral and pharmacological serotonergic mechanisms in rats. Eur.J.Pharmacol. 196 85. PMID: 1831423.
Maryanoff et al (1990) Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J.Med.Chem. 33 2793. PMID: 2213832.
Shank et al (1988) McN-5652: a highly potent inhibitor of serotonin uptake. J.Pharmacol.Exp.Ther. 247 1032. PMID: 2905001.
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Keywords: (±)-McN 5652, supplier, Potent, orally, active, 5-HT, reuptake, inhibits, inhibitors, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, (±)-McN5652, McN5652Z, Tocris Bioscience, 5-HT Transporter Inhibitor products
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