Cat. No. 2147

Nicorandil C8H9N3O4 [65141-46-0]

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Chemical Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide

Biological Activity

Kir6 (KATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing Kir6 channels (EC50 values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

Soluble to 20 mM in water
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gomma et al (2001) Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 61 1705. PMID: 11693460.

Horinaka et al (2001) Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 38 200. PMID: 11483869.

Shindo et al (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br.J.Pharmacol. 124 985. PMID: 9692785.

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Citations are publications that use Tocris products.

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Keywords: Nicorandil, supplier, KATP, channel, openers, NO, donor, Potassium, KIR, Channels, Inward, Rectifier, K+, ROS, Donors, Precursors, Nitric, Oxide, Signaling, Signalling, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products

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