AIDA

Cat. No. 0904

AIDA
 C11H11NO4 [168560-79-0]

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Alternative Name: UPF 523

Chemical Name: (RS)-1-Aminoindan-1,5-dicarboxylic acid

Biological Activity

A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
221.21
Formula:
C11H11NO4
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
168560-79-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Moroni et al (1997) Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist. J.Pharmacol.Exp.Ther. 281 721. PMID: 9152378.

Nielsen et al (1997) Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur.J.Pharmacol. 326 105. PMID: 9196260.

Pellicciari et al (1995) 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors. J.Med.Chem. 38 3717. PMID: 7562903.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AIDA include:

Saitoh et al (2016) Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation Scientific Reports 6 29856. PMID: 27432639.

De-May and Ali (2013) Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. J Neurophysiol 109 216. PMID: 23054605.

Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186. PMID: 22496564.

Wibrand et al (2010) Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. Eur J Neurosci 31 636. PMID: 20384810.

Pan et al (2004) Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats. BMC Neurosci 5 50. PMID: 15579204.

Do you know of a great paper that uses AIDA from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

Keywords: AIDA, supplier, Potent, selective, group, I, antagonist, Group, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, UPF523, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products

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