CRF (human, rat)

Cat. No. 1151

CRF (human, rat) Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

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Alternative Name: Corticotropin-Releasing Factor (human, rat)

Biological Activity

Endogenous peptide agonist for the CRF receptor (Ki values are 11, 44 and 38 nM for hCRF1, rCRF2a and mCRF2b respectively). Stimulates the synthesis and release of ACTH from the anterior pituitary.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data


(Modifications: Ile-41 = C-terminal amide)

Soluble to 1.10 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Perrin et al (1999) Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J.Pharmacol.Exp.Ther. 288 729. PMID: 9918582.

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663.

Rivier et al (1986) Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion. Annu.Rev.Physiol. 48 475. PMID: 2871808.

Souza et al (1984) Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification. Science 224 1449. PMID: 6328656.

Tache et al (1983) Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Science 222 935. PMID: 6415815.

Vale et al (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213 1394. PMID: 6267699.

If you know of a relevant reference for CRF (human, rat) please let us know.

Citations are publications that use Tocris products. Selected citations for CRF (human, rat) include:

Klampfl et al (2016) CRF-R1 activation in the anterior-dorsal BNST induces maternal neglect in lactating rats via an HPA axis-independent central mechanism. J Neuroinflammation 64 89. PMID: 26630389.

Song et al (2016) Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia. J Neurosci 13 63. PMID: 26968975.

Gray et al (2015) Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety. J Neurosci 35 3879. PMID: 25740517.

Navarro et al (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Psychoneuroendocrinology 35 6639. PMID: 25926444.

Lowery-Gionta et al (2012) Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci 32 3405. PMID: 22399763.

Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407. PMID: 18184783.

Dermitzaki et al (2007) Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Endocrinology 148 1524. PMID: 17194738.

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Keywords: CRF (human, rat), supplier, Stimulates, ACTH, release, Corticotropin-Releasing, Factor, Non-Selective, CRF, Receptors, agonists, Tocris Bioscience, Non-selective CRF Receptor Agonist products

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