Cat. No. 1146
Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-va
Biological ActivityPotent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960. PMID: 17600513.
Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17. PMID: 9637399.
Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188. PMID: 9374290.
Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150. PMID: 1877091.
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Citations are publications that use Tocris products. Selected citations for MDL 28170 include:
Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835. PMID: 25341622.
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