MDL 28170

Cat. No. 1146

MDL 28170 C22H26N2O4 [88191-84-8]

Price and Availability

For MDL 28170 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Technical Data

M.Wt:
382.45
Formula:
C22H26N2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
88191-84-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960. PMID: 17600513.

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17. PMID: 9637399.

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188. PMID: 9374290.

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150. PMID: 1877091.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MDL 28170 include:

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835. PMID: 25341622.

Do you know of a great paper that uses MDL 28170 from Tocris? If so please let us know.

Keywords: MDL 28170, supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Tocris Bioscience, Calcium-Sensitive Protease Modulator Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.