MDL 28170

Cat. No. 1146

MDL 28170 C22H26N2O4 [88191-84-8]

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Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal

Biological Activity

Potent, selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

Technical Data

Soluble to 100 mM in DMSO
>95 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ai et al (2007) Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury. J.Neurotrauma 24 960. PMID: 17600513.

Li et al (1998) Postischemic treatment with a calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia. Neurosci.Lett. 247 17. PMID: 9637399.

Chen et al (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL 28170. Brain Res. 769 188. PMID: 9374290.

Mehdi (1991) Cell-penetrating inhibitor of calpain. TiBS 16 150. PMID: 1877091.

If you know of a relevant reference for MDL 28170 please let us know.

Citations are publications that use Tocris products. Selected citations for MDL 28170 include:

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. J Neurosci 6 9173. PMID: 25823819.

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835. PMID: 25341622.

Do you know of a great paper that uses MDL 28170 from Tocris? If so please let us know.

Keywords: MDL 28170, supplier, Potent, selective, calpain, cathepsin, B, inhibitors, inhibits, Proteinases, Proteases, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, MDL28170, Tocris Bioscience, Calcium-Sensitive Protease Modulator Inhibitor products

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