Dibutyryl-cAMP, sodium salt
Cat. No. 1141
Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt
Biological ActivityCell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Xia et al (2016) Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci.Rep. 6 20270. PMID: 26842779.
Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235. PMID: 9679177.
Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139. PMID: 9600931.
Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233. PMID: 1847496.
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Citations are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:
Park et al (2005) Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 289 H2461. PMID: 16284107.
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Keywords: Dibutyryl-cAMP, sodium salt, supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, cAMP-dependent, protein, kinase, PKA, Kinase, A, differentiation, Tocris Bioscience, cAMP products