Dibutyryl-cAMP, sodium salt

Cat. No. 1141

Dibutyryl-cAMP, sodium salt C18H23N5NaO8P [16980-89-5]

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Chemical Name: N6,O2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt

Biological Activity

Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Promotes differentiation of dopaminergic neurons (iDA) from hPSCs in combination with other reagents.

Technical Data

M.Wt:
491.37
Formula:
C18H23N5NaO8P
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
16980-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Xia et al (2016) Transcriptional comparison of human induced and primary midbrain dopaminergic neurons. Sci.Rep. 6 20270. PMID: 26842779.

Carranza et al (1998) Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235. PMID: 9679177.

Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139. PMID: 9600931.

Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233. PMID: 1847496.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dibutyryl-cAMP, sodium salt include:

Park et al (2005) Activation of inward rectifier K+ channels by hypoxia in rabbit coronary arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 289 H2461. PMID: 16284107.

Do you know of a great paper that uses Dibutyryl-cAMP, sodium salt from Tocris? If so please let us know.

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Keywords: Dibutyryl-cAMP, sodium salt, supplier, Cell-permeable, cAMP, Cyclic, adenosines, Monophosphate, Inositol, Signaling, Signalling, cAMP-dependent, protein, kinase, PKA, Kinase, A, differentiation, Tocris Bioscience, cAMP products

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