CGP 54626 hydrochloride

Cat. No. 1088

CGP 54626 hydrochloride C18H28Cl2NO3P.HCl [149184-21-4]

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Chemical Name: [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid

Biological Activity

A potent, selective GABAB receptor antagonist (IC50 = 4 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Technical Data

M.Wt:
444.76
Formula:
C18H28Cl2NO3P.HCl
Solubility:
Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>96 %
Storage:
Store at RT
CAS No:
149184-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kaupmann et al (1998) GABAB-receptor subtypes assemble into functional heteromeric complexes. Nature 396 683. PMID: 9872317.

Froestl et al (1996) Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm. 8 127.

Brugger et al (1993) The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat. Eur.J.Pharmacol. 235 153. PMID: 8390938.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CGP 54626 hydrochloride include:

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015. PMID: 26052039.

Pfeffer et al (2013) Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci 16 1068. PMID: 23817549.

Baloucoune et al (2012) GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS One 7 e39698. PMID: 22761875.

Tani et al (2010) Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci 30 1288. PMID: 20107056.

Tu et al (2010) GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 30 749. PMID: 20071540.

Root et al (2008) A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron 59 311. PMID: 18667158.

Dzitoyeva et al (2003) Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A 100 5485. PMID: 12692303.

Do you know of a great paper that uses CGP 54626 hydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CGP 54626 hydrochloride, supplier, Potent, selective, GABAB, antagonists, Receptors, CGP54626, hydrochloride, Tocris Bioscience, GABAB Receptor Antagonist products

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