R18

Cat. No. 2144

R18 Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro

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Biological Activity

Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

Technical Data

M.Wt:
2309.69
Formula:
C101H157N27O29S3
Sequence:
PHCVPRDLSWLDLEANMCLP
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
211364-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Masters et al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30 360.

Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193. PMID: 11577088.

Wang et al (1999) Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display. Biochemistry 38 12499. PMID: 10493820.

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Keywords: R18, supplier, inhibitors, inhibits, 1433, proteins, induces, apoptosis, 14-3-3, 14.3.3, Tocris Bioscience, 14.3.3 Protein Inhibitor products

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