Cat. No. 2143
Chemical Name: Salicylidene salicylhydrazide
Biological ActivityPotent and selective partial inhibitor of β1-containing GABAA receptors (IC50 values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABAA receptors respectively). May bind allosterically to a novel site on GABAA receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Thompson et al (2004) Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABAA receptors. Br.J.Pharmacol. 142 97. PMID: 15100159.
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Citations are publications that use Tocris products. Selected citations for SCS include:
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 16 8. PMID: 25887256.
Limon et al (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol 109 10071. PMID: 22691495.
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Keywords: SCS, supplier, Selective, GABAA, receptor, antagonists, beta1-subunit-selective, Receptors, Tocris Bioscience, GABAA Receptor Antagonist products