Cat. No. 2142
Biological ActivityHighly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
(Modifications: Met-28 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111. PMID: 12467628.
If you know of a relevant reference for [Ala11,D-Leu15]-Orexin B please let us know.
Citations are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:
Moore et al (2014) Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse. Respir Physiol Neurobiol 200 118. PMID: 24929062.
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004. PMID: 22652455.
Shahid et al (2012) Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex. Br J Pharmacol 165 2292. PMID: 21951179.
Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol 156 1326. PMID: 19751316.
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Keywords: [Ala11,D-Leu15]-Orexin B, supplier, Potent, selective, OX2, receptor, agonists, Orexin2, Receptors, [Ala11D-Leu15]-OrexinB, Tocris Bioscience, OX2 Receptor Agonist products
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November 8 - 10, 2017