Cat. No. 2141
Chemical Name: (3S,4R)-3-[(1,3-Benzodioxol-5-yloxy
Biological ActivityHighly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fujishiro et al (2002) Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. Eur.J.Pharmacol. 454 183. PMID: 12421645.
Bourin et al (2001) Paroxetine: a review. CNS Drug Rev. 7 25. PMID: 11420571.
Owens et al (1997) Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305. PMID: 9400006.
Thomas et al (1987) Biochemical effects of the antidepressant paroxetine, a specific 5-hydroxytryptamine uptake inhibitor. Psychopharmacology 93 193. PMID: 2962217.
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Citations are publications that use Tocris products. Selected citations for Paroxetine maleate include:
Steiner et al (2015) Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. J Neurosci 12 200. PMID: 25404050.
Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. BMC Neurosci 29 13909. PMID: 19890001.
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Keywords: Paroxetine maleate, supplier, potent, selective, 5-HT, reuptake, inhibitors, inhibits, serotonin, inhibitor, transporters, SERT, 5-Hydroxytryptamine, monoamine, neurotransmitter, Tocris Bioscience, 5-HT Transporter Inhibitor products
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