Cat. No. 1467
Alternative Name: Daunomycin
Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,
Biological ActivityAnticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6. PMID: 16930453.
Laurent and Jaffrezou (2001) Signaling pathways activated by daunorubicin. Blood 98 913. PMID: 11493433.
Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.
Aubel-Sadron and Londos-Gagliardi (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66 333. PMID: 6380596.
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Citations are publications that use Tocris products. Selected citations for Daunorubicin hydrochloride include:
Jones et al (2013) An alternative direct compound dispensing method using the HP D300 digital dispenser. PLoS One 18 367. PMID: 23708834.
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Keywords: Daunorubicin hydrochloride, supplier, RNA, synthesis, inhibitors, inhibits, antibiotics, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
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