Daunorubicin hydrochloride

Cat. No. 1467

Daunorubicin hydrochloride C27H29NO10.HCl [23541-50-6]

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Alternative Name: Daunomycin

Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

Biological Activity

Anticancer agent that is clinically used to treat nonlymphocytic leukemia. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.

Technical Data

M.Wt:
563.99
Formula:
C27H29NO10.HCl
Solubility:
Soluble to 50 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
23541-50-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6. PMID: 16930453.

Laurent and Jaffrezou (2001) Signaling pathways activated by daunorubicin. Blood 98 913. PMID: 11493433.

Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem.Pharmacol. 57 727. PMID: 10075079.

Aubel-Sadron and Londos-Gagliardi (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66 333. PMID: 6380596.

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Keywords: Daunorubicin hydrochloride, supplier, RNA, synthesis, inhibitors, inhibits, antibiotics, chemotherapeutics, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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