Cat. No. 2952
Alternative Name: N-acetyldinaline
Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)be
Biological ActivityOrally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Gräff et al (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156 261. PMID: 24439381.
Beckers et al (2007) Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 121 1138. PMID: 17455259.
Kraker et al (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2 401. PMID: 12700284.
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Keywords: CI 994, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, CI994, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products