Cat. No. 2952
Alternative Name: N-acetyldinaline
Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)be
Biological ActivityOrally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gräff et al (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156 261. PMID: 24439381.
Beckers et al (2007) Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int.J.Cancer 121 1138. PMID: 17455259.
Kraker et al (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma. Mol.Cancer Ther. 2 401. PMID: 12700284.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CI 994 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: CI 994, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, CI994, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products
Find multiple products by catalog number
New Products in this Area
HDAC5 and HDAC9 inhibitorMC 1742
Potent class I and IIb HDAC inhibitorYK 3-237
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.