SKF 81297 hydrobromide
Cat. No. 1447
Chemical Name: (±)-6-Chloro-2,3,4,5-tetrahydro-1-ph
Biological ActivityDopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Reavill et al (1993) Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297. Behav.Pharmacol. 4 135. PMID: 11224180.
Peacock et al (1990) The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 186 49. PMID: 1980891.
Arnt et al (1988) Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 62 121. PMID: 3259694.
If you know of a relevant reference for SKF 81297 hydrobromide please let us know.
Citations are publications that use Tocris products. Selected citations for SKF 81297 hydrobromide include:
Meunier et al (2015) Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS One 10 e0120286. PMID: 25775449.
Pezze et al (2015) Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Mol Med Rep 232 2669. PMID: 25820982.
Parnaudeau et al (2014) Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci 8 35. PMID: 24574986.
Marley et al (2013) GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. Psychopharmacology (Berl) 8 e70857. PMID: 23936473.
Guha et al (2012) Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem 122 823. PMID: 22639870.
Olianas et al (2012) Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex. Neurosignals 21 61. PMID: 22456324.
Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Neurosci 7 624. PMID: 21785426.
Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. PLoS One 13 1128. PMID: 20711186.
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Keywords: SKF 81297 hydrobromide, supplier, D1, agonists, Dopamine, Receptors, D5, dopaminergic, SKF81297, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Agonist products
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