Xenin 8

Cat. No. 2138

Xenin 8 His-Pro-Lys-Arg-Pro-Trp-Ile-Leu

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Alternative Names: Xenopsin-related peptide 1, XP-1

Biological Activity

C-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.

Technical Data

M.Wt:
1046.28
Formula:
C51H79N15O9
Sequence:
HPKRPWIL
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
117442-28-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697. PMID: 14654163.

Silvestre et al (2003) Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25. PMID: 12873795.

Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303. PMID: 2460902.

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Keywords: Xenin 8, supplier, Neurotensin-like, peptide, potentiates, insulin, glucagon, secretion, NT, Receptors, Xenin8, Xenopsin, related, peptide1, Tocris Bioscience, Neurotensin Receptor Agonist products

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