Cat. No. 2138
Alternative Names: Xenopsin-related peptide 1, XP-1
Biological ActivityC-Terminal fragment of xenin, a neurotensin-like peptide; modulates pancreatic insulin and glucagon secretion/effects. Stimulates basal and arginine-induced insulin secretion and potentiates the insulin response to glucose (EC50 = 0.16 nM). Also potentiates arginine- and carbachol-induced glucagon secretion in a somatostatin-independent manner.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Feurle et al (2003) Metabolism and potency of xenin and of its reduced hexapseudopeptide ψ fragment in dog. Life Sci. 74 697. PMID: 14654163.
Silvestre et al (2003) Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul.Pept. 115 25. PMID: 12873795.
Carraway et al (1988) Xenopsin-related peptide generated in avian gastric extracts. Regul.Pept. 22 303. PMID: 2460902.
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Keywords: Xenin 8, supplier, Neurotensin-like, peptide, potentiates, insulin, glucagon, secretion, NT, Receptors, Xenin8, Xenopsin, related, peptide1, Tocris Bioscience, Neurotensin Receptor Agonist products
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