Cat. No. 1131
Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuran
Biological ActivityAntagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95. PMID: 12409010.
Chan et al (1997) The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent insulin secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 120 926. PMID: 9138700.
Chan et al (1997) Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 356 763. PMID: 9453462.
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Citations are publications that use Tocris products.
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Keywords: KU14R, supplier, Antagonists, pancreatic, imidazoline, receptors, I3, Receptors, Tocris Bioscience, I3 Receptor Antagonist products