KU14R

Cat. No. 1131

KU14R C13H14N2O [189224-48-4]

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Chemical Name: 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole

Biological Activity

Antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.

Technical Data

M.Wt:
214.27
Formula:
C13H14N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
189224-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95. PMID: 12409010.

Chan et al (1997) The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent insulin secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 120 926. PMID: 9138700.

Chan et al (1997) Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 356 763. PMID: 9453462.

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Keywords: KU14R, supplier, Antagonists, pancreatic, imidazoline, receptors, I3, Receptors, Tocris Bioscience, I3 Receptor Antagonist products

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