Dexamethasone

Cat. No. 1126

Dexamethasone C22H29FO5 [50-02-2]

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Chemical Name: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

Biological Activity

Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.

Technical Data

M.Wt:
392.47
Formula:
C22H29FO5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
50-02-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Sittichokechaiwut et al (2010) Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell. Eur.Cell Mater. 20 45. PMID: 20648425.

Laane et al (2009) Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16 1018. PMID: 19390558.

Matasic et al (1999) Dexamethasone inhibits dendritic cell maturation by redirecting differentiation of a subset of cells. J.Leukoc.Biol. 66 909. PMID: 10614771.

Teixeira et al (1996) Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig. Br.J.Pharmacol. 118 317. PMID: 8735633.

Merck Index 12 2986.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dexamethasone include:

Bullers et al (2014) The human tissue-biomaterial interface: a role for PPARγ-dependent glucocorticoid receptor activation in regulating the CD163+ M2 macrophage phenotype. Tissue Eng Part A 20 2390. PMID: 24548290.

Knutson et al (2014) Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One 9 e111840. PMID: 25493630.

Do you know of a great paper that uses Dexamethasone from Tocris? If so please let us know.

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Keywords: Dexamethasone, supplier, Anti-inflammatory, glucocorticoid, receptor, Receptors, induces, differentiation, Tocris Bioscience, Glucocorticoid Receptor products

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