Salvinorin A

Cat. No. 2134

Salvinorin A C23H28O8 [83729-01-5]

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Alternative Name: Divinorin A

Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester

Biological Activity

Potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties. .

Technical Data

M.Wt:
432.47
Formula:
C23H28O8
Solubility:
Soluble to 10 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
83729-01-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801. PMID: 17060492.

Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107.

Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Salvinorin A include:

Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273. PMID: 22537770.

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Keywords: Salvinorin A, supplier, potent, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, SalvinorinA, DivinorinA, Tocris Bioscience, κ Opioid Receptor Agonist products

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