[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
Cat. No. 1172
Biological ActivityVIP receptor antagonist; inhibits [125I]iodo-VIP binding and selectively inhibits VIP- and GRF-induced effects on adenylyl cyclase.
(Modifications: Tyr-1 = N-terminal Ac, Phe-2 = D-Phe, Arg-29 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nowak et al (1994) Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist. Neuropeptides 27 297. PMID: 7862261.
Waelbroeck et al (1985) Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology 116 2643. PMID: 2859987.
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