BMY 14802 hydrochloride
Cat. No. 1440
Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyr
Biological ActivityPotent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.
Licensing InformationSold with the permission of Bristol-Myers Squibb Company
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125. PMID: 8232511.
Zhang et al (1993) Further characterization of the effects of BMY 14802 on dopamine neuronal activity. Synapse 15 276. PMID: 7908761.
Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516. PMID: 1361578.
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Citations are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:
Paquette et al (2008) σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111. PMID: 18281903.
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Keywords: BMY 14802 hydrochloride, supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Tocris Bioscience, Sigma-Related Antagonist products
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June 14 - 17, 2017
Boston, MA, USA