BMY 14802 hydrochloride

Cat. No. 1440

BMY 14802 hydrochloride C18H22F2N4O.HCl [105565-55-7]

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Chemical Name: α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride

Biological Activity

Potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1A and α1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Technical Data

M.Wt:
384.86
Formula:
C18H22F2N4O.HCl
Solubility:
Soluble to 25 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
105565-55-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125. PMID: 8232511.

Zhang et al (1993) Further characterization of the effects of BMY 14802 on dopamine neuronal activity. Synapse 15 276. PMID: 7908761.

Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516. PMID: 1361578.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for BMY 14802 hydrochloride include:

Paquette et al (2008) σ ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111. PMID: 18281903.

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Keywords: BMY 14802 hydrochloride, supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Tocris Bioscience, Sigma-Related Antagonist products

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