Cat. No. 1442
Chemical Name: [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl
Biological ActivityNon-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM).
Licensing InformationSold with the permission of Bristol-Myers Squibb Company
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rudd et al (2000) Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 129 782. PMID: 10683203.
Seiler et al (1997) [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins 53 21. PMID: 9068064.
Meanwell et al (1993) Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid. 36 3884. PMID: 7504734.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BMY 45778 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: BMY 45778, supplier, Non-prostanoid, prostacyclin, IP1, receptor, partial, agonist, Receptors, Prostanoid, PGI, prostaglandins, prostacyclins, eicosanoids, BMY45778, Tocris Bioscience, Prostanoid Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonistAMG 853
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonistAM 4668
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonistPPTN hydrochloride
High affinity and selective P2Y14 antagonistItraconazole
SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2017.