BMY 45778

Cat. No. 1442

BMY 45778 C26H18N2O5 [152575-66-1]

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Chemical Name: [3-(4,5-Diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]acetic acid

Biological Activity

Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM).

Licensing Information

Sold with the permission of Bristol-Myers Squibb Company

Technical Data

M.Wt:
438.44
Formula:
C26H18N2O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
152575-66-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Rudd et al (2000) Non-prostanoid prostacyclin mimetics as neuronal stimulants in the rat: comparison of vagus nerve and NANC innervation of the colon. Br.J.Pharmacol. 129 782. PMID: 10683203.

Seiler et al (1997) [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (BMY 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, cAMP levels, protein kinase, and iloprost binding. Prostaglandins 53 21. PMID: 9068064.

Meanwell et al (1993) Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid. 36 3884. PMID: 7504734.

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Keywords: BMY 45778, supplier, Non-prostanoid, prostacyclin, IP1, receptor, partial, agonist, Receptors, Prostanoid, PGI, prostaglandins, prostacyclins, eicosanoids, BMY45778, Tocris Bioscience, Prostanoid Receptor Agonist products

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