Cat. No. 1460

PACOCF3 C17H31F3O [141022-99-3]

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Alternative Name: Palmityl trifluoromethyl ketone

Chemical Name: 1,1,1-Trifluoro-2-heptadecanone

Biological Activity

Phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.

Technical Data

Soluble to 25 mM in DMSO and to 50 mM in ethanol
>99 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jan et al (2000) Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch.Toxicol. 74 447. PMID: 11097381.

Lio et al (1996) Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim.Biophys.Acta 1302 55. PMID: 8695655.

Ackermann et al (1995) Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J.Biol.Chem. 270 445. PMID: 7814408.

If you know of a relevant reference for PACOCF3 please let us know.

Citations are publications that use Tocris products. Selected citations for PACOCF3 include:

Qiu et al (2014) GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex. J Neurosci 34 13505. PMID: 25274827.

Potapova et al (2013) Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. J Neurosci 8 e73929. PMID: 24069252.

Do you know of a great paper that uses PACOCF3 from Tocris? If so please let us know.

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Keywords: PACOCF3, supplier, Phospholipases, A2, inhibitors, inhibits, PLA2, Esterases, Tocris Bioscience, Phospholipase Inhibitor products

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