AACOCF3

Cat. No. 1462

AACOCF3 C21H31F3O [149301-79-1]

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Alternative Name: Arachidonyl trifluoromethyl ketone

Chemical Name: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one

Biological Activity

Inhibitor of cytosolic (85 kDa) phospholipase A2. Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro.

Technical Data

M.Wt:
356.47
Formula:
C21H31F3O
Solubility:
Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
Storage:
Desiccate at -20°C
CAS No:
149301-79-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Rastogi and McHowat (2009) Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. Respir.Physiol.Neurobiol. 165 167. PMID: 19059366.

Koutek et al (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J.Biol.Chem. 269 22937. PMID: 8083191.

Riendeau et al (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. J.Biol.Chem. 269 15619. PMID: 8195210.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AACOCF3 include:

Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249. PMID: 24258815.

Bianca et al (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110 15812. PMID: 24019484.

Do you know of a great paper that uses AACOCF3 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: AACOCF3, supplier, FAAH, inhibitors, inhibits, Phospholipases, A2, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, PLA2, Esterases, Cannabinoids, Receptors, Tocris Bioscience, Phospholipase Inhibitor products

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