Apoptosis Activator 2

Cat. No. 2098

Apoptosis Activator 2 C15H9Cl2NO2 [79183-19-0]

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Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Technical Data

M.Wt:
306.14
Formula:
C15H9Cl2NO2
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
79183-19-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Alavian et al (2009) Elevtaed p75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 4 11. PMID: 19291307.

Jayaraman and Pike (2009) Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones. J.Neuroendocrinol. 21 77. PMID: 19094096.

Nguyen and Wells (2003) Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc.Natl.Acad.Sci.USA 100 7533.

If you know of a relevant reference for Apoptosis Activator 2 please let us know.

Citations are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

Stankiewicz et al (2005) Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. PLoS One 280 38729. PMID: 16172114.

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Keywords: Apoptosis Activator 2, supplier, Promotes, apoptosome, formation, activates, caspase-9/caspase-3, pathway, Selectively, induces, tumor, cell, apoptosis, Selective, Proteinases, Proteases, Inducer, Apoptosis, Activator2, Tocris Bioscience, Caspase products

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