SKI II

Cat. No. 2097

SKI II C15H11ClN2OS [312636-16-1]

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Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Biological Activity

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).

Technical Data

M.Wt:
302.78
Formula:
C15H11ClN2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
312636-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596. PMID: 16632640.

French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SKI II include:

Xun et al (2015) Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res 34 94. PMID: 26337959.

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Keywords: SKI II, supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Tocris Bioscience, Sphingosine Kinase Inhibitor products

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