Cat. No. 2097
Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]
Biological ActivitySelective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596. PMID: 16632640.
French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862.
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Citations are publications that use Tocris products. Selected citations for SKI II include:
Reid et al (2015) Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex. Am J Nephrol 4 e61. PMID: 26576339.
Xun et al (2015) Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res 34 94. PMID: 26337959.
Kim et al (2010) Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. J Biol Chem 31 353. PMID: 20234131.
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Keywords: SKI II, supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Tocris Bioscience, Sphingosine Kinase Inhibitor products
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